Inhalation Toxicology

TSI Recognizes the Significance of Nanomaterials and Their Potential Health Effects

As many are aware, nanomaterials exhibit unique material properties; similarly, it is thought that nanomaterials may also possess unique human health effects. One of the primary human exposure routes to nanomaterials is via inhalation, so in vivo (‘within the living’) inhalation toxicology studies are required to research potential health effects.

Nanomaterials of specific composition and size are generated and fed into inhalation chambers where precisely quantified dosages are administered to test subjects, and specific biological responses are documented versus dose rates. The size and concentration of the chosen challenge aerosol has a large affect on the level of exposure (respiratory deposition rates) and the particular toxicological effects.

inhalation toxicology 

TSI Offers Instruments to Assess Nanoparticles for Inhalation Toxicology Studies

TSI aerosol generation instruments like the Electrospray Aerosol Generator 3480 and the Electrostatic Classifier 3080 are used to generate repeatable, controlled challenge aerosols with extremely narrow size distributions. Precision aerosol sizing and counting instruments like the Scanning Mobility Particle Sizer (SMPS) Spectrometer*, and Condensation Particle Counters (CPCs) are used to accurately determine the dose given to the test subjects.

Contact one of TSI’s application experts to find out more about how TSI aerosol generators, sizers and counters can help with specific nanomaterial inhalation toxicology experiments.

*Fully Compliant with ISO 10808:2010: Characterization of nanoparticles in inhalation exposure chambers for inhalation toxicity testing.


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