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Nanomaterial Toxicology

TSI Recognizes the Significance of Nanomaterials and Their Potential Health Effects

Nanomaterials exhibit unique material properties and it is believed that nanomaterials may also possess unique human health effects. Inhalation is one of the primary human exposure routes to nanomaterials, so in vivo ('within the living') inhalation toxicology studies are required to research potential health effects.

Nanomaterials of specific composition and size are generated and fed into inhalation chambers where precisely quantified dosages are administered to test subjects, and specific biological responses versus dose rates are documented. The size and concentration of the chosen challenge aerosol has a large effect on the level of exposure (respiratory deposition rates) and the particular toxicological effects.

inhalation toxicology

TSI Offers Instruments to Assess Nanoparticles for Inhalation Toxicology Studies

TSI aerosol generation instruments, like the Electrospray Aerosol Generator 3482 and the Electrostatic Classifier 3082, are used to generate repeatable, controlled challenge aerosols with extremely narrow size distributions. Precision aerosol sizing and counting instruments, like the Scanning Mobility Particle Sizer (SMPS) Spectrometer* and Condensation Particle Counters (CPCs) are used to accurately determine the dose given to the test subjects.

To find out more about how TSI aerosol generators, sizers and counters can help with specific nanomaterial inhalation toxicology experiments, contact one of TSI's application experts. 

*Fully Compliant with ISO 10808:2010: Characterization of nanoparticles in inhalation exposure chambers for inhalation toxicity testing .

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